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doi:10.1089/ARS.2009.2695 Morris D, Khurasany M, Nguyen T, et al

This study demonstrated that cultured hepatocytes treated either with a precursor of GSH, such as L-cysteine or N-acetylcysteine, or with its soluble ethyl ester form, boosts the levels of cellular GSH, which upregulates CYP27A1, CYP27B1, and VDR but downregulates CYP24A1

AG-221, a small molecule mutant IDH2 inhibitor, remodels epigenetic state of IDH2-mutant cells and induces alterations in self-renewal/differentiation in IDH2-mutant AML model in vivo