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In addition, ~60% of the variance in the severity of the neuropsychiatric symptoms is explained by the cumulative effects of decreased SpO2 and increased PBT (thus, the severity of the acute infectious phase) coupled with increased CRP and OSTOX/ANTIOX ratio

Front Physiol 9: 349, 2018

However, based upon recent, empirical observations by numerous clinicians and researchers, another scenario has emerged: that certain individuals are predisposed towards ELEVATED, or up-regulated CBS pathway activity