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doi: 10.1016/j.clim.2008.02.015 133 BottegaRPersicoIDe SetaFRomanoFDi LorenzoG

In the central nervous system, iron is an essential element that is involved in many important biological processes in brain, such as oxygen transportation, myelin production, and the synthesis of neurotransmitters (Ward et al., 2014)

Parasitology 136 , 1859 (2009)

Especially, we revealed that HIF-1 activated GPX4 transcription in colonic epithelial cells by binding to the GPX4 promoter to inhibit ferroptosis in UC