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Intrahepatic GSH can detoxify NAPQI generated from APAP by the conjugation, but there was no significant difference in intrahepatic GSH level between unchallenged WT and IL-1ra KO mice

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Artemisinin originates from isopentenyl diphosphate (IPP) or dimethylallyl diphosphate (DMAPP) via the methylerythritol phosphate (MEP) pathway in the plastid or via the mevalonate (MVA) pathway in the cytosol 70

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