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For example, an RCT administered 400 mcg/day folic acid and 500 mcg/day vitamin B12 (B-vitamin group) or a placebo for 2 years to 2,919 adults age 65 and older with homocysteine levels of 12 to 50 mcmol/L [95]

Mood Regulation : B12 is involved in producing brain chemicals that regulate mood and mental function

Patients with existing diabetes or kidney disease can have more adverse effects like further reducing the kidney function

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