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Transcriptome analyses of cells with acute TCAi showed robust activation of the response to amino acid deprivation

The field moves rapidly toward more effective, better-tolerated, and more personalized metabolic therapies

Rare but serious side effects include allergic reactions

129 , 130 Practically, hypoxia not only facilitates the proliferation, migration and invasion of HCC cells, but also hastens malignant progression by affecting the crosstalk between stromal cells, tumour cells and immune cells in the TME