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3.3 Comparison between PoD and exposure estimates for the use scenarios Figure 8 shows the PoD medians for all readouts in which benchmark chemical-induced bioactivity (either up or downregulation) were observed

This creates a fundamental design trade-off: optimizing for superior tissue penetration often comes at the cost of plasma persistence, and vice versa

Venn diagram of the SG proteome identified after AS treatment, comparing in-house data with published datasets

These coordinated molecular perturbations manifest physiologically as systemic glucose disposal deficits, compensatory hyperinsulinemia, and progressive advancement toward metabolic syndrome

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