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The C282Y substitution is rare outside the white ethnicity although other mutations do exist [13]

For example, inhibition of ATR leads to accumulation of unrepaired cytoplasmic DNA, activates cGAS-STING pathway and induces type I interferon secretion, which enhances T cell infiltration and antitumor immunity (200,201)

ZanichelliFCapassoSCipollaroMPagnottaECartenMCasaleFet al

Phosphatidylinositol 4,5-bisphosphate (PIP 2 ) controls magnesium gatekeeper TRPM6 activity

Ethnic Variations [Ref] Hispanic population: This group shows the highest frequency for the C677T mutation, with up to 47% carrying at least one copy of the variant