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Lett Drug Des Discovery 16(10):11671174 Laun AS et al

Stress increased depressive-like behavior, evaluated by longer immobility time in the forced swimming test, in addition to altering the expression of microRNAs and genes related to neurotransmission in different brain regions

In contrast, cancers with high expression of only one or two enzymes display metabolic flux redirection or environmental dependence, requiring combination strategies targeting transporter bypass pathways or microenvironmental remodeling cascades