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In fact, GSNO reductase-dependent oxidation of HMGSH is increased 8-fold in the presence of GSNO in vitro and more than 20-fold in crude lung and liver lysates

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Here, we report on an Fc-engineered variant with three amino acid substitutions Q311R/M428E/N434W (REW), that enhances plasma half-life and mucosal distribution, as well as allows for needle-free delivery across respiratory epithelial barriers in human FcRn transgenic mice

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