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However, tesofensine faces significant challenges - cardiovascular side effects (increased heart rate and blood pressure) raised safety concerns, FDA has not approved it despite promising efficacy data, development stalled after Phase 3 trials, currently available only through research chemical suppliers with questionable legality, and the stimulant-like mechanism creates dependency and tolerance risks not seen with GLP-1 agonists

Many practitioners recommend splitting daily doses: 250 mcg morning and evening for improved consistency

Drink adequate amounts of water to facilitate nutrient absorption and ensure overall health

I wish I had tried it sooner instead of suffering through those two years

B12's role in maintaining a healthy nervous system makes it a valuable addition to the treatment plan for cats facing these challenges