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Acidosis-induced activation of GPR4 promotes the endoplasmic reticulum (ER) stress response and apoptosis of endothelial cells (177, 179, 180)

Epigenetic therapy for cardiovascular disease DNA methylation DNA methyltransferase inhibitors or related drugs play a role in the treatment of cardiovascular diseases such as coronary heart disease and heart failure by regulating target genes methylation status and expression level (Figs

JAK/STAT was a common signal transduction pathway activated by many cytokines

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A significant decrease in daily calories intake was observed in the low-carbohydrate group (from 2205 624 kcal to 1667 404 kcal, p = 0.004), whereas no significant change occurred in the high-carbohydrate group