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10.2174/1381612824666180614082950 39 KlicekR.KolencD.SuranJ.DrmicD.BrcicL.AralicaG.et al (2013)

ARBU (at mg/mL doses) reduces PCSK9 protein expression and potentiates LDLR signaling, which reduces cholesterol availability and promotes tumor cell apoptosis ( Therapeutic activation of LXR by the agonist RGXX-104 has been found to reduce MDSCs and enhance the response of cytotoxic T lymphocytes in both mice and patients

Its important to monitor your skins response over time and consult with a healthcare provider to ensure safe and effective use of the supplement