Antibodies against Chac1, c-Myc (9E10), HA, LC3 and Actin were purchased from Abcam (UK), Santa Cruz Biotechnology (U.S.A.), Clontech Laboratories (U.S.A.), Medical & Biological Laboratories (Japan) and Calbiochem (U.S.A.), respectively
Bednarek M, Maciejewski J, Wozniak M, et al
No routine trending of: Individual defect types (e.g., hair, glass, atypical particulate) This approach limited: Early detection of contamination signals Data-driven escalation and intervention Aseptic Process and Environmental Monitoring Weaknesses Environmental monitoring failures linked to: Occluded equipment surfaces Surfaces not reliably exposed to (b)(4) decontamination High-risk interventions: Involved stopper handling and equipment manipulation Occurred within ISO 5 environments Were already identified as risky in internal assessments, yet remained permitted Sampling methodology: Use of contact plates with sweeping motion Inability to attribute contamination to specific surfaces Reduced sensitivity compared to swab sampling for irregular or critical surfaces SEE ALSO: Types of Sampling Methods in Environmental Monitoring Stopper Control as a Contamination Risk Reliance on pre-shipment (tailgate) samples supplied by stopper vendors
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Neurology 96:e772e782 Taximaimaiti R, Luo X, Wang XP (2021) Pharmacological and non-pharmacological treatments of sleep disorders in Parkinsons disease
