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10.3390/ijms241511902 Int

To maintain optimal levels of glutathione, the body relies on a recycling process that converts oxidized glutathione back into its reduced form

NRF2 regulates GSH biosynthesis and related metabolic enzymes, including GCL, GSS, and SLC7A11, all of which are indispensable for GSH synthesis (111)

Further, the colloidal stability of the formulation in circulation and membrane destabilization and hexagonal phase II conversion following exposure to the acidic TME due to the presence of DOPE (37.5%) in the liposome membrane could contribute to the enhanced Dox release within the tumor tissue 17

Lipid nanoparticles (SLN, NLC): overcoming the anatomical and physiological barriers of the eyePart IBarriers and determining factors in ocular delivery