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The knockdown of XCT which encodes SLC7 A11, can induce M1 polarization by interfering with the SOCS3-STAT6-PPAR pathway (Tang 2023)

This makes ozone therapy a gentle option for those who may be sensitive to other treatments or medications

In the immune response, tumor cells exhibit high levels of CD47 expression, which impedes phagocytosis by macrophages through its binding to SIRP on the macrophage surface, thereby facilitating immune evasion

In the near future, the metabolite profile of individual patients can be used as an important tool for predicting the disease course and improving the treatment

However, under stress conditions, HMOX1 is capable of translocating to other cellular membranous compartments