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Although the precise mechanisms underlying the beneficial effects of ALA has not yet been fully understood, by successfully clarifying the manifold hepatoprotective function of ALA, this study sheds an important light for potential use of ALA as a dietary supplement to prevent, or even to counteract, the metabolic dysfunction induced by chronic sleep deprivation, a condition increasingly prevalent in our modern society

By improving liver function and fat transport, and supporting energy production through B12, they can make an active, calorie-controlled lifestyle more effective

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Smyth MJ, Cretney E, Kelly JM, Westwood JA, Street SE, Yagita H

Phase 2 trial data (Jastreboff et al., NEJM 2023) demonstrated average weight reductions of approximately 1724% over 48 weeks notably higher than currently approved GLP-1 receptor agonists such as semaglutide, though direct comparisons are limited by differences in trial populations and designs