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S5a), which corresponded with the higher expression of PSAT and SHMT2 in SCCs over NC and AdCs (Fig

Indeed, LDHB silencing resulted in a significant increase in mitochondrial lipid peroxidation not only in the NSCLC cell line A549, the malignant pleura mesothelioma (MPM) cell line MSTO-211H, the fibrosarcoma cell line HT1080, and the pancreatic ductal carcinoma cell lines PANC-1 (Fig

Caspase-8-induced pyroptosis occurs simultaneously with NLRP3 activation and IL-1 secretion (32)

This, in turn, elevated ROS production, which increased HIF-1 levels and ultimately upregulated PCNA expression, promoting cell proliferation

H-rZ: Methodology, Investigation, Writing original draft