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The complexes I and III of mitochondrial ETC produces superoxide anion (Rodriguez and Redman, 2005)

2 DNA methylation and tumor 2.1 Process and mechanism of DNA methylation In a broad sense, DNA methylation refers to the chemical modification of methyl binding to a specific base on DNA through a covalent bond, which may occur at the C-5 position of cytosine, N-6 position of adenine, and N-7 position of guanine (Ahmad and Rao, 1996)

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2 Early symptoms may include gastrointestinal disturbances such as nausea, vomiting, and abdominal pain, which may progress to more severe manifestations, including jaundice, hepatic encephalopathy, and coagulopathy in patients with advanced liver injury

Pinsent J