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Their main adverse effect is skin atrophy, which manifests clinically as epidermal thinning, telangiectasia, spontaneous striae, fissuring, and hypertrichosis ( In summary, the BHG exhibits excellent biocompatibility and potent antibacterial activity, effectively reducing serum levels of IL-4, IL-13, IgE, and histamine in AD mice, and alleviating clinical symptoms including erythema, exudation, crusting, and pruritus

Several enzymatic and non-enzymatic defence mechanisms that guard cells against free radical damage have been identified in different cellular localizations, including mitochondria, plasma membrane, endoplasmic reticulum, peroxisomes, and cytosol