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conducted combined docking and MD simulations for the binding of dopamine, amphetamine, orphenadrine, and cocaine in the hDAT model

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The advantage of this type of compounds, apart from the reduction in side effects, is their efficient metabolism to non-toxic products and a high affinity for specific molecular targets, which can potentially be associated with enhanced treatment efficacy, enabling the use of a relatively low dose to produce identical biological effects [3]

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