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Commonly Reported Side Effects Nausea , often described as dose-sensitive

79 ZhangA.JiangM.ZhangJ.DingH.XuS.HuX.et al (2007)

MTHFR is directly involved in the metabolism of folate and is considered to have direct consequences to cancer incidence if the enzymatic function is partly lost

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Seek medical evaluation if constipation persists beyond 3 days, involves severe cramping, blood in stool, or fever above 100.4F, as these may indicate serious underlying conditions