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Smith, T

J Clin Endocrinol Metab

J., Haber, M., Preston-Martin, S., Schoenberg, J

The Double-Edged Sword: Neurotoxicity of Chemotherapy

Elevated NAD+ levels activate sirtuins, particularly SIRT1, which are NAD+-dependent deacetylases that regulate numerous metabolic processes including fat oxidation, glucose metabolism, mitochondrial biogenesis, and cellular stress responses