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Expression reconstitution with wild-type IRE1, but not the endoribonuclease (RNase)-dead K907A mutant, re-sensitized IRE1-null MDA-MB-231 cells to ferroptosis induction (Fig

The total score and C-score were recorded for a comprehensive evaluation of the docking effect

Although, this has been supported by the findings that pharmacological inhibition of 15-LOX-1 exerts a cytoprotective effect (Seiler et al., 2008

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