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Recently, non-covalent inhibitors of SmTGR, presenting antischistosomal efficacy in an animal model of infection, were developed targeting the doorstop pocket (here site S3), which further validates this pocket as a druggable site 96

Further details regarding the reactions identified by the algorithm are available in Supplementary Data 5

All the output datasets for the morphometric analysis of the mitochondrial and neurite networks were compiled across experimental groups and statistically compared with the control samples using unpaired t -tests

Depletion of luminal Ca 2+ , either during normal cellular physiology or upon addition of pharmacological agents, provokes a rapid and reversible shift towards a more reducing redox state of the luminal [GSH] 2 :[GSSG] ratio [13, 23, 24]

Some women experience high blood sugar during pregnancy