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Additionally, animal model may have different tolerance and compensative mechanism for mitophagy impairment 49 and ROS stress 234,235

The term refers to a cluster of feelings and behaviors, brought on by a variety of underlying causes

5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia

Additionally, it is proposed that targeting ferroptosis is a potential treatment for pulmonary diseases, particularly drug-resistant lung cancer or antibiotic-resistant pulmonary infection, and reduces treatment-related adverse events

In recent years, multiple experimental therapies aiming to induce ferroptosis have been developed for cancer treatment