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RSL3 does not inhibit cystine uptake and yet triggers an otherwise similar iron and ROS-dependent ferroptototic death program

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3.1.1 Phytochemicals The polyphenols, especially flavonoids, are abundant antioxidants in human diets, primarily found in plant-based foods and linked to the Mediterranean diet, which is associated with lower cardiovascular disease mortality

Furthermore, exosomes derived from human umbilical cord blood mesenchymal stem cells were administered to mice following MI, effectively preventing cardiomyocyte death from ferroptosis and reducing heart damage

The formazan product was solubilized with sodium dodecylsulfate (SDS, 10%, m v 1 in 20 mM HCl), and the absorbance was measured at 595 nm relative to the absorbance of vehicle (DMSO)-treated control cells using a multiwell scanning spectrophotometer (Victor 3 plate reader, PerkinElmer, Rodgau-Juegesheim, Germany)