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For example, Icarin was confirmed to inhibit ECM degradation and ferroptosis in chondrocytes, thereby alleviating articular cartilage damage in OA rats by restoring SLC7A11 and GPX4 expression (Xiao et al., 2024)

L342, 159

465,466 This activation is predominantly mediated through the disruption of the Kelch-like ECH-associated protein 1 (KEAP1) - NRF2 interaction (oxidation of KEAP1 Cys151, Cys273, and Cys288), 29 facilitating the translocation of NRF2 into the nucleus

Key active ingredients include Sodium Bicarbonate, BPC-157, and Hyaluronic Acid

The management of diabetes and the suppression of -glucosidase enzyme activity both seem to include the active compound mangiferin (391)