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Therefore, mitochondrial diseases can result from both maternally inherited mtDNA mutations and classical genetic mutations in nDNA (1)

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Teclistamab in relapsed or refractory multiple myeloma

Collectively, our in vivo and in vitro findings are consistent with TMAO aggravating kidney fibrosis due to ERK1/2 hyperactivation synergistically, probably with activation of the TGF-1-mediated SMAD3 pathway causing a secondary hit in our disease model