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TDP-43 pathology was originally defined with the accumulation of proteins that include phosphorylated TDP-43 (pTDP-43) in the cytoplasm of neurons that undergo degeneration 10 , and this pathology was broadly observed in a wide spectrum of ALS cases 44

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The number of metabolites regulated by XJZ, XJZ-P, XJZ-A, and XJZ-C were 15, 7, 10, and 13, respectively (Figure S5c)

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