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Excessive aggregation of A can excessively induce inflammatory responses, further damaging neurons and synapses, ultimately leading to widespread brain damage and cognitive impairment [38]

Nouv Presse Med 6(27):2449 Gomes BAQ, Silva JP, Romeiro CF, Dos Santos SM, Rodrigues CA, Goncalves PR, Sakai JT, Mendes PF, Varela EL, Monteiro MC (2018) Neuroprotective mechanisms of resveratrol in Alzheimers disease: role of SIRT1

Alagebrium (ALT-711), a thiazolium derivative, is the best-known and most widely studied AGE crosslink breaker in clinical research

Nature 399 (6736), 601605

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