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This rest was associated with increased SRC and mitochondrial mass and decreased mitochondrial membrane potential, fundamental metabolic features associated with memory T cell precursors and superior antitumor activity 6,7,18

It is generally reserved for compounds that demonstrate poor solubility, clumping, precipitation, cloudiness, or gel formation

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Although genetic alterations contribute to resistance, increasing evidence indicates that epigenetic regulation and non-genetic cellular plasticity are primary drivers of drug-tolerant and relapse-initiating states

Chromatographic analysis was performed using the Shimadzu high-performance liquid chromatography (HPLC) system composed of two quaternary pumps, an autosampler (model 20ACHT), and a diode array detector (DAD) (model SPD-M20A) and a C18 (ODS) reverse phase (150 mm 4.5 mm) column