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Vitamin B12 is a vital dietary nutrient, and a deficiency of vitamin B12 can lead to peripheral neuropathy, megaloblastic anaemia, and many other serious conditions

It is used in research settings to investigate cytoprotective signaling and tissue-repair mechanisms, including experimentally reported effects in preclinical models relevant to gastrointestinal mucosal integrity, angiogenic signaling, and inflammatory modulation

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[204], Al Senaidy [205], and other authors [97,114,206,207,208,209,210,211], asthmatics, independent of age, have a lower intake and levels of vitamin A and general carotenoids, even without showing any signs of deficiency