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Furthermore, prolonged treatment with 5-AZA and DAC (48 h) has a more significant impact on DNMT1 depletion, the induction of DNA damage, and the upregulation of gene expression [153]

5 Limitations and future directions of research Given the scope of the present study, several key factors warrant acknowledgment: First, bridging the translational gap between animal models and human clinical applications is challenging

The slow titration schedule described in the dosing section is specifically designed to minimize these effects

They work within the context of overall health, including sleep, exercise, nutrition, social connection, and professional mental health support

[ CrossRef ] [ Google scholar ] Bobyntsev II, Chernysheva OI, Dolgintsev ME, Smakhtin MY, Belykh AE