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Cardiovascular and malignancy screening are standard practice before initiation

J Cancer Res Clin Oncol 142(5):913925

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in addition, chronic accumulation of such metals is known to increase the risk for neurodegenerative disorders, particularly of AD and PD

Furthermore in lentigo maligna the proliferation of melanocytes extends along the external root sheath of the hair follicles, even to the base of the hair follicle