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The research above (Badenhorst, Finkley, Abdulghani, Carey/Pickart) all studied topical application

Treasure Island (Florida): StatPearls Publishing (2023)

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coli as an MBP fusion, resulted in enhanced soluble expression of stable, functional protein [53]

Audet and collaborators found that DOR activated by SNC-80 strongly interacts with arrestin 3 (Audet et al., 2008): when the receptor is phosphorylated by GRK2 and internalized via arrestins it can recycle whereas in a non-phosphorylated form DOR undergoes an arrestin-independent sequestration which is followed by a degradation