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In a randomized, double-blind, placebo-controlled pilot clinical trial thiamine was given orally to 24 patients with type 2 diabetes mellitus for 1 month and was found to decrease fasting blood glucose levels and leptin concentrations [80]

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Docosahexaenoic acid protection against palmitic acid-induced lipotoxicity in NGF-differentiated PC12 cells involves enhancement of autophagy and inhibition of apoptosis and necroptosis