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Of note, the large phase 3 trials are sponsored by pharmaceutical companies, whereas the observed rise of phase 2 investigator-initiated studies indicates an enhanced global effort to investigate novel immunotherapy strategies

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Furthermore, the dysbiosis of the gut microbiota triggers intestinal mucosal barrier damage, leading to inflammation and disordered nutrient metabolism [62]

141,143148 Several lines of evidence have indicated that extracellular loops (EL1 and EL2) of claudins are important for both trans - and cis -claudinclaudin interactions

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