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A recent clinical study reported increased synaptic density measured by positron emission tomography imaging targeting synaptic vesicle protein 2 A in elderly depressed individuals who achieved remission following ECT [122]

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In addition, neuronal MCT2 plays a unique role in long-term memory consolidation, and its knockdown in mature neurons also impairs hippocampal neurogenesis, revealing that MCT2 function extends beyond metabolic support to the regulation of plasticity-related processes

In cardiovascular models, the effective treatment doses vary