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GH-mediated downstream effects (hepatic IGF-1 production, anabolic signaling) are the proposed basis for claimed metabolic benefits, but the evidence base is limited to animal and in vitro research

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Two authors independently searched electronic databases including MEDLINE, EMBASE, Cochrane Library, Web of Science, PubMed and Google scholar from 1990 until February 2019, in order to find relevant RCTs