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Several pharmacological agents and natural compounds (e.g., rapamycin, losartan, sirolimus, and andrographolide) show efficacy in experimental CD models by modulating specific cell death pathways

doi: 10.3390/ijms24054562 86 NieschlagEVoronaE

Using a four-point rating system, patients indicate how much they have experienced each symptom (or item) over the past seven days (1 = Not at all, 2 = A little bit, 3 = Quite a little, and 4 = Very much)