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When astrocytes take up glutamate, not only is there post-synaptic attenuation of nearby neurons, but within the astrocyte there is a switch from oxidative metabolism to aerobic glycolysis, and glucose is diverted from the TCA cycle to glycolysis and greater lactate production

In diabetic nephropathy, up-regulated CD36 promotes free fatty acid (FFA) uptake, whereas down-regulated ABCA1 hinders extracellular transport of phospholipids and cholesterol

Erythroblastic islands-associated tissue-resident ferritin-enriched macrophages perform a function of erythroblast nurse cells, supporting their survival and maturation, providing iron supply for hemoglobin synthesis, promoting proliferation via secreting erythropoiesis-enhancing factors such as IGF-1 and IL-18, and ensuring elimination of phosphatidylserine-exposing pyrenocytes, which represent the extruded nuclei formed within the enucleation process [47,48,49]

Regarding the point, it is well-established that one of the most common complications seen in IBD patients is iron deficiency anemia (IDA) [601]

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