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10.1038/ncb3064 Nat Cell Biol

We eat a poor quality, inflammatory diet, have imbalances in the microbiome (dysbiosis), are exposed to toxins on a daily basis, take medications that disrupt the gut and are under an incredible amount of stress

the skin lesions usually take the form of a purplish rash (or less often an exfoliative dermatitis) involving the nose, cheeks, forehead, upper trunk, and arms