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Ruger L, Yang E, Coutermarsh-Ott S, Vickers E, Gannon J, Nightengale M, Hsueh A, Ciepluch B, Dervisis N, Vlaisavljevich E, et al (2023): Histotripsy ablation for the treatment of feline injection site sarcomas: a first-in-cat in vivo feasibility study

Questions remaining include optimal human dosing, long-term safety, effects across different populations, interactions with diet and exercise, and whether benefits extend beyond weight loss to improvements in cardiometabolic disease outcomes

In contrast, for RRMS, the initial therapy recommendations typically involve DMTs to reduce disease activity and relapse

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Ex vivo studies sit between test-tube experiments and full clinical trials on the evidence scale