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Comment Hepatocellular hypertrophy, secondary to increase in microsomal enzymes often occurs with a zonal or specific lobular pattern and commonly occurs following exposure to enzyme inducing xenobiotics

It has been reported that at least two DAMPs, namely mutant KRAS protein [172] and the DNA oxidation product 8-hydroxyguanosine/8-OHG [37], are released by ferroptotic cells to mediate macrophage polarization through the activation of AGER/RAGE (advanced glycosylation end-product specific receptor) and STING1/STING/TMEM173 (stimulator of interferon response cGAMP interactor 1) pathways, respectively

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Persistence of viral components, such as S protein, has been hypothesized to be responsible for long COVID-associated neurological symptoms 57,58,59