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Recessive Epidemiology: 5 patients Genetics Mutations: Compound heterozygote

2a,b, Supplementary Fig

Rutin treatment also upregulated key ovarian steroidogenic enzymes (STAR, 17-HSD, 3-HSD, aromatase, and P450C17), normalized LH levels and estrous cyclicity, reduced cystic follicle formation, and significantly improved ovulation, fertility, and birth outcomes