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Physiol Rep

Using random forest regression as the predictive model, we identified pathways commonly associated with NRF2, such as reactive oxygen species (ROS) and xenobiotic metabolism, in addition to reduced glutathione and NADP levels, as top features associated with NRF2 dependency (Fig

In vitro radiosensitization effect of MbO 2 @Gd-NTs and the synergistic effect between Gd-Tex and oxygen We first investigated if Mb/Hb-loaded nanotexaphyrins could relieve hypoxia of tumor cells

3.3.3 Local iron homeostasis and the joint microenvironment Pathological changes such as increased vascular permeability or microbleeding in subchondral bone can also lead to local iron deposition

Spermatozoa have the highest selenium content in mammalian tissues, and the need for selenium increases at the onset of spermatogenesis ( 2.5 GPX5 Glutathione peroxidase 5 (GPX5), an epididymis-specifically expressed selenium-free antioxidant enzyme, was first isolated and identified in the epididymal tissues of mice ( During epididymis transport, spermatozoa are vulnerable to intracellular and extracellular ROS attacks and rely on antioxidant scavengers synthesized by the epididymis for protection