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An international survey of patients with tetrahydrobiopterin deficiencies presenting with hyperphenylalaninaemia

FreeSurfer regional segmentation was then performed on the unbiased template image, and the hippocampal formation mask was generated by binarizing and combining the labels corresponding to the hippocampus and the entorhinal cortex, while an extended hippocampal formation mask was additionally generated to also include the parahippocampal cortex

This distinction becomes clinically relevant for anyone with MASLD, elevated liver enzymes, or metabolic syndrome components beyond obesity

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