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Since plasma levels of IGF-I are important mediators of most of the peripheral actions of GH, it is reasonable to assume that there must be important relationships between IGF-I and gastric ghrelin secretion

These compounds activate the Nrf2 pathway, a cellular signaling system that upregulates expression of genes involved in antioxidant production including glutathione synthesis enzymes

Oxidative damage increases through exposure to UV radiation, pollution, pesticides, and smoke, as well as a diet high in inflammatory foods or low in antioxidant-rich foods

More globally, the development of phMRI and other molecular imaging biomarkers can reveal therapeutic mechanisms, which will allow drug development and treatment to be tailored toward specific neural circuits and patient populations

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