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In addation, after 2 h of drug administration, the DOX concentration of Fe 3 O 4 @DOX@RBM (magnetic field) treatment in tumor tissues was 190.400.65 g/mL, which was significantly higher than that of theFe 3 O 4 @DOX@RBM (59.650.27 g/mL), suggesting the potent tumor-targeting capability of Fe 3 O 4 @DOX@RBM (magnetic field) due to the magnetic targeting effect of Fe 3 O 4 nanoparticles (Figure S6)